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    We used a probe-based dual-modality optical imaging instrument to measure in vivo coating thickness distributions of a gel distributed along the vaginal lumen, in a clinical study. The gel was a surrogate for one delivering an anti-HIV topical microbicide. Imaging data from Fourier-domain multiplexed low-coherence interferometry mLCI and fluorimetric measurements were compared to assess the feasibility and accuracy of mLCI in measuring in vivo gel coating thickness distributions. In each study session, 3. The participant either: 1.
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    High resolution optical imaging by confocal reflectance microscopy CRM was investigated for revealing epithelial microstructure and alterations which may occur from vaginal microbicides. The vaginal tract was removed and imaged by CRM without staining and imaged regions were then biopsied and processed for histology. In control mice, CRM revealed columnar epithelium and lamina propria with features resembling that of histology.
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